Healthy Microbiota Lowers Alzheimer's Risk

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Providing information about the disease on September 21, World Alzheimer's Day, Neurology Specialist Dr. Yüksel Dede pointed out that the risk of developing Alzheimer's disease doubles every 60 years after the age of 10. exp. Dr. Dede drew attention to studies showing that healthy gut microbiota reduces this risk.

In order to reduce the devastating effects of Alzheimer's disease in the world and in Turkey, and to detect the disease at an early stage, September 21 was designated as World Alzheimer's Day. Reminding that the number of dementia patients in the world has exceeded 47 million at the moment, Yeditepe University Koşuyolu Hospital Neurology Specialist Dr. Yüksel Dede said that this figure is predicted to exceed 2050 million in 130. Explaining that different researches on the subject are continuing, Uzm. Dr. Yüksel Dede gave important information on the relationship between Alzheimer's and microbiota, which is one of the topics that has been studied recently.

Underlining that Azheimer's is a problem that affects the whole society, regardless of man or woman, Uzm. Dr. Yüksel Dede said, “Since the life expectancy of women is higher than that of men, the gender gap is especially evident over the age of 85. As a result, the proportion of women is higher in the Alzheimer's patient population over the age of 85. Alzheimer's disease is seen at a rate of approximately 5 to 7 percent in the age-adjusted prevalence.

RESEARCH ON MICROBIOTA AND ALZHEIMER CONTINUES

Stating that the entire ecosystem formed by many beneficial and harmful organisms such as bacteria, viruses and fungi in our digestive system is defined as microbiota. Yüksel Dede said, “There are studies showing that the better a person's microbiota, the better the course of Alzheimer's disease and the lower the probability of getting the disease. It has been shown that even in diabetes and blood pressure patients, who are at risk of experiencing dementia, these risks will decrease after people pay attention to a healthy diet and treat their disease effectively. In this regard, it is seen that the improvement in the course of the disease increases with the education level of the people.

BENEFICIAL BACTERIA HAVE AN ANTIBIOTIC EFFECT

"Both animal studies and studies based on groups of people, including Alzheimer's patients, show that good microbiota reduces the likelihood of developing Alzheimer's disease," said Dr. Yüksel Dede gave the following information on how the microbiota has an effect on Alzheimer's: “The multitude of beneficial bacteria has an antibiotic effect on the harmful ones. Intestinal permeability increases with toxins produced by harmful bacteria or cell damage caused by them. Due to these permeability, harmful substances produced by bacteria in the digestive tract, taken from the outside or formed in the canal, pass through the intestine to other organs, especially the brain. These harmful substances that pass into the brain trigger an inflammation in the brain and cause cell damage and cell death there. Alzheimer's disease is the same zamIt is caused by an increase in amyloid plaques in the brain. The resulting inflammation can cause these plaques to increase and bud. So a good microbiota is a good factor as it will reduce intestinal permeability and the presence of such harmful substances in the environment. same zamAt the same time, beneficial bacteria also provide the synthesis of some amino acids and vitamins in our intestines. These, of course, have a protective effect," he said.

Reminding that there is no scientific study showing that bad microbiota is a direct triggering factor for Alzheimer's disease, Dr. Dr. Yüksel Dede said, “Especially Alzheimer's patients who are diagnosed early before the age of 60 generally have a genetic cause. There is no study directly on the relationship between early-onset Alzheimer's disease or inherited Alzheimer's disease and microbiota. However, having a bad microbiota on top of an individual with a genetic predisposition will contribute negatively to the course of the disease.

EAT MEDITERRANEAN TYPE

Yeditepe University Hospitals Neurology Specialist, who recommends a Mediterranean type diet with plenty of fiber-rich fruits and vegetables for a healthy microbiota. Dr. Yüksel Dede said, “There are researches done in this field. Products such as yoghurt and kefir rich in probiotic bacteria, plenty of vegetables and fruits can be consumed. Vitamin deficiencies should also be avoided. Vitamins B, C, D are important vitamins for the brain. Apart from this, regular exercise and mental activities should be done to prevent Alzheimer's disease. zammoment must not be abandoned. The higher a person's education level, the more they continue their mental activities, the less likely they are to develop Alzheimer's disease. Even at an advanced age, for example, by learning a new language, zamIt is necessary to keep the mind fresh at the moment," he said.

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